Our lab is interested in healthy aging, focusing on understanding the balance between aging and disease states. Specifically, we want to elucidate the regulation mechanism of polyamine homeostasis, which is a meta-hallmark of both aging and tumor. To that end, we combine computational and experimental methods. 

      1. We want to study how protein-protein interaction (PPI) networks (modules) are sustained by protein-protein interaction. Using the polyamine metabolism network as a model, we want to understand how PPI regulates polyamine homeostasis.

      2. We developed the covalent drug discovery protocol SCARdock, the first protocol for discovering covalent ligands based on non-covalent docking. We aim to improve the efficiency and expand the application of this protocol. For example, we want to use SCARdock to discover novel covalent ligands targeting undruggable proteins, acting as inhibitors, molecular glues, or PROTACs.

      3. We want to study protein function by the design of protein structure, function, affinity, and orthogonality. On one side, we want to design functional proteins such as industrial enzymes. On the other side, we are interested in understanding how PPI could be targeted for functional protein design.